vAO: Variant Annotator for OncoKB™ is an easy-to-use software tool designed to help researchers and clinicians quickly identify and annotate genomic variants from solid tumors. It allows users to analyze large datasets without needing programming skills. By supporting both genomic coordinate-based and amino acid alteration-based annotation, vAO can process data in formats like VCF and Microsoft Excel, and it offers flexibility in choosing genome builds (GRCh37/38). The tool generates simple and intitutive results providing information on the oncogenicity of variants, available targeted drugs, and their impact on genes. This makes it easier to explore variant data and identify potential therapies, helping advance precision oncology research.
If you are using the tool for your research, please cite:ESMO TAT 2025
If you are using the OncoKB™ API, please check their website for citation details: OncoKB™